I think one of the more important things that Neal Goldsmith (shameless plug-he is a friend. buy his new book!) points out about psychedelics is that it any therapeutic/spiritual benefit that we derive is not so much an effect of pharmacology, or, by extension, of the particular substance that we take, but rather a function of whether we achieve a "peak" or "mystical" experience. This is a lesson that would be well-taken by our community, I think, because we often give a great deal of consideration to the various minutae regarding the massively variegated set of psychedelic drugs we have at our disposal--and this is certainly interesting, all the more so if I can say that a methoxy group here tends to cause this sort of trend in the subjective experience, and it is this sort of investigation that lead me into serious study of the drugs--but to a certain extent emphasizing the differences between drugs can cause us to miss the boat, and variety of experience can cheapen the depth of the experience.